Granular-cell myoblastoma of the anterior uvea.

Case Report A 24-year-old white woman was first seen in consultation in September, 1960, complaining of a "little vein" in the nasal side of the sclera of the right eye, which had been growing over a period of three months without symptoms, but three days previously she complained of sudden pain and "severe loss of vision". Examination.-Right eye: A salmon-pink solid mass was seen growing inside the anterior chamber occupying its superior and nasal quadrant (Fig. 1). It seemed to have a tense capsule and was richly vascularized. The pupillary border was displaced to the temporal side. The cornea was clear and the growth was not in contact with its posterior face. The temporal iris was normal, as also were the lens, vitreous, retina, and optic disc. Tension was 8/5 5. Left eye: Normal. Operation.-The tumour was removed via an ab externo excision with a limbus-based conjunctival flap. Part of the iris was adherent to the posterior face of the tumour and a complete iridectomy was carried out nasally. The tumour was not completely removed and part of it remained in connexion with the ciliary body. The patient recovered very well and the last time she was seen, one year after operation, the eye was completely quiet without any sign of recurrence. Pathological Examination.-Microscopically the tumour consisted of a solid undifferentiated mass of large polyhedral cells with distinct cell membranes and small round or oval nuclei; some were binuclear. Within the abundant cytoplasm were many coarse, pale, eosinophilic granules. There was no tendency for alveolar grouping of the cells, the growth was entirely devoid of stroma, and no mitotic figures were found. A rich reticulin network was present between the cells and it showed a "tufting appearance". The cytoplasmic granules were weakly positive with periodicacid-Schiff stain, strongly positive with Sudan black, and stained red with Masson's trichrome stain (Figs. 2 and 3).